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Home - Products - Chromatin/Epigenetic - HMTase - EPZ020411 dihydrochloride

EPZ020411 dihydrochloride

CAS No. 2095432-47-4

EPZ020411 dihydrochloride( EPZ 020411 )

Catalog No. M13294 CAS No. 2095432-47-4

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    EPZ020411 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8.
  • Description
    EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7); dose-dependently decreases H3R2 methylation A375 cell line with IC50 of 0.637 uM, with no affect levels of PRMT6 expression; exhibits good bioavailability following subcutaneous dosing in rats making it a suitable tool for potential in vivo target validation studies.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    EPZ 020411
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    2095432-47-4
  • Formula Weight
    515.52
  • Molecular Formula
    C25H40Cl2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CNCCN(C)CC1=C(NN=C1)C2=CC=C(C=C2)OC3CC(C3)OCCC4CCOCC4.Cl.Cl
  • Chemical Name
    1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]-,dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Apr 6;6(6):655-9.
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